Hata, A., & Mukai, Y. (2014). Itai-itai byo to Fukushima: koremade no 100 nen korekara no 100 nen (in Japanese, Itai-itai disease and Fukushima: previous 100 years and next 100 years). Tokyo: Goto Shoin. Suwazono Y, Kido T, Nakagawa H, Nishijo M, Honda R, Kobayashi E, Dochi M, Nogawa K (2009) Biological half-life of cadmium in the urine of inhabitants after cessation of cadmium exposure. Biomarkers 14:77–81

Han J, Wang S, Fan D, Guo Y, Liu C, Zhu Y (2019) Time-dependent hormetic response of soil alkaline phosphatase induced by Cd and the association with bacterial community composition. Microb Ecol 78:961–973 Honda, R., Tsuritani, I., Ishizaki, M., Kido, T., Yamada, Y., & Nogawa, K. (1989). Flameless atomic absorption spectrophotometry of cadmium and lead in blood and urine. J Kanazawa Med Univ, 14(3), 337–347 (Abstract in English). Nogawa K, Sakurai M, Ishizaki M, Kido T, Nakagawa H, Suwazono Y (2017) Threshold limit values of the cadmium concentration in rice in the development of itai-itai disease using benchmark dose analysis. J Appl Toxicol 37(8):962–966The gin boom, or ginaissance, is still going strong, with the British public buying more of the juniper-based tipple than ever before. Sartor F, Rondia D, Claeys F, Buchet JP, Ducoffre G, Lauwerys R, Staessen J, Amery A. Factors influencing the cadmium body burden in a population study. IARC Sci Publ. 1992;118:101–6. Aoshima K, Katoh T, Teranishi H, Horiguchi H, Kasuya M. Abnormalities of calcium, phosphorus and vitamin D metabolism with proximal renal tubular dysfunction in subjects environmentally exposed to cadmium. Jpn J Hyg. 1993;47:1009–20. (in Japanese with English abstract) Yoshioka, K. (1961). Jinzu-gawa suikei kogai kenkyu hokokusho (in Japanese, Report on mining pollution study of Jinzu River and its tributaries), self-publishing. Later published in Yoshioka, 1971, 5–95. The present study is the first report to clarify the final disease stages of patients with Itai-itai disease who suffered from severe renal tubular dysfunction and osteomalaecia. However, 184 patients with Itai-itai disease who died before the starting baseline survey in 1979 and 41 patients who died from 1979 to 1981 were not included as subjects of the primary cohort study, because the baseline survey was conducted from 1979 to 1984. Autopsy was generally performed in Toyama University Hospital after 1979, but only 12 autopsy cases were reported between 1955 and 1977. 4 Therefore, the present study is limited in the recruitment of patients with Itai-itai disease who died in the 1970s. Matsuda et al conducted a 15-year follow-up survey targeting highlyexposed residents in the Jinzu River basin, including patients with Itai-itai disease who died in the 1970s before our baseline survey, but they only reported increased mortality risk ratio for all causes of death in the residents with renal tubular dysfunction. 11

Jinzu was launched in 2014 and was the invention of Dee Davis, an English bartender who created it a year earlier as an entrant to Diageo’s Show Your Spirit competition – which he won. Recommended serves of this 41.3 % spirit are Indian tonic and green apple, but it is also enjoyable supped neat, with a very passing resemblance to those cherry menthol sweets for sore throats, but in a far, far more subtle and pleasing way. Teeyakasem W, Nishijo M, Honda R, Satarug S, Swaddiwudhipong W, Ruangyuttikarn W (2007) Monitoring of cadmium toxicity in a Thai population with high-level environmental exposure. Toxicol Lett 169:185–195 This tasty gin is exactly as quoted on the bottle and above – and is yet another find from our trusty Gin Scouts, Bill and Lesley. Jinzu Gin is distilled in Scotland yet is presented with a very Japanese style of painting on the bottle depicting cherry branches and blossom. Its name also giving a hint of the anomalous treasures within and apparently named after Japan’s Jinzu River, which is lined with thousands of cherry trees. Nogawa, K., Suwazono, Y., & Kido, T. (2019). Long-term follow-up study of residents exposed to cadmium in Kakehashi River basin, Ishikawa, Japan. In: Himeno S., Aoshima K. (eds) Cadmium toxicity. Current topics in environmental health and preventive medicine. Springer, Singapore. p 51–p 61. https://doi.org/10.1007/978-981-13-3630-0_4.Hayano M, Nogawa K, Kido T, Kobayashi E, Honda R, Tsuritani I. 1996 Dose-response relationship between urinary cadmium con-.587 centration and â 2-micro-globulinuria using logistic regression analysis. Arch Environ Health 51, 162–167. Itai-itai byo sosho bengo-dan (the defense counsel of Itai-itai disease suit), Ed. (1972). Itai-itai byo saibain (in Japanese, Itai-itai disease lawsuit) Vol. 3. Tokyo: Sogo Tosho. Ministry of Agriculture, Forestry and Fisheries of Japan. Monitoring of cadmium concentration of rice in rice-producing areas of Japan. http://www.maff.go.jp/j/syouan/nouan/kome/k_cd/documents/02_mon.html. Hawkesworth S, Wagatsuma Y, Kippler M, Fulford AJC, Arifeen SE, Persson LA, Moore SE, Vahter M (2013) Early exposure to toxic metals has a limited effect on blood pressure or kidney function in later childhood, rural Bangladesh. Int J Epidemiol 42:176–185